The department „Translational Medical Oncology“ of the German Cancer Re-search Center (DKFZ) at the National Center for Tumor diseases (NCT) Dresden focuses on the functional and molecular characterization of malignant cell regu-lation and metastasis formation. We have established and extensively character-rized biobanks of patient-derived in vivo and in vitro cancer models and investi-gated clonal dynamics and regulation of tumor-initiating cell (TIC) activity in gas-trointestinal cancers (e.g. Cell Stem cell 2011; Cancer Letters 2016; EMBO Mol Med 2017; IJC 2017; JEM 2017; Nature Genetics 2017). For specific targeting of TIC activity, we have evaluated the impact of novel therapeutic approaches on primary patient derived tumor models. Global insertional mutagenesis gene ac-tivation and pooled shRNA knock down screens allowed identification of candi-date genes potentially critical for proliferation, tumor and metastasis formation. In addition, the department drives a precision oncology program for genomic analysis of patient cancers as a basis for interventional clinical trials (NCT MAS-TER). This program has demonstrated that whole-exome/genome and RNA se-quencing in a clinical setting provides relevant diagnostic information and crea-tes opportunities for pharmacologic intervention.
We are looking for a highly motivated postdoctoral fellow with significant expe-rience in cell and molecular biology as well as cancer research. The successful candidate will contribute to establishing individualized oncology at the NCT Dresden. The MASTER workflow provides comprehensive analysis of individual tumors’ structural exome and transcriptome alterations and provides a basis for identifying, understanding and targeting of patient-specific vulnerabilities in personalized cancer models. Supplementing descriptive genetic information with mechanistic testing of functional and therapeutic consequences in appropriate individualized cancer models will be essential to support clinical interpretation towards innovative approaches of diagnosing, classifying and treating cancer.
Applicants should hold a PhD degree in biology/life sciences with an excellent background in cellular and molecular biology as well as cancer biology, or closely related fields. The applicants should be highly self-motivated and be able to pur-sue and drive research projects independently as well as in collaborations. An ex-cellent written and oral command of English is essential. Applications should in-clude a CV, cover letter, certificates, expected availability date, a complete list of publications and 2-3 references.
Duration: The position is initially limited to 2 years.
Contact: Dr. Heidrun Groß, phone +49 351 458 5239.
Application Deadline: April 4, 2018
The position can in principle be part-time.