Header Forschung

Research Group Genetic Predisposition

The NCT/UCC Research Group “Genetic Predisposition” focuses on the identification of disease causing germline variants/alterations in children with cancer with a special focus on acute leukemia of childhood, as well as the elucidation of the oncogenic capacity of these genetic variants in regard to environmental exposures.

Methodology

  • Trio-sequencing of child-parent trios in children newly diagnosed with cancer
  • Analysis of the sequencing data for known classical cancer predispositions and VUS
  • Transfection, Transduction, Knockdown and Overexpression in cell systems
  • CRISPR-Cas9 based technologies
  • Protein biochemical methods (Western Blot, Immunoprecipitation, Reporter gene assays)
  • Sequencing methods (NGS, Sanger-sequencing, Deep-Sequencing) (in cooperation)
  • Transgenic mouse models

Team

Prof. Dr. Julia Hauer
Group Leader
Phone: +49 (0)351 458 3522
E-Mail: Julia.Hauer(at)uniklinikum-dresden.de

Carolin Melzig
Technical Assistant
Email: carolin.melzig(at)nct-dresden.de

Dr. Franziska Auer
Post-Doc
Phone: +49 (0)351 4179
E-Mail: Franziska.Auer(at)uniklinikum-dresden.de

Rajanya Ghosh
PhD Student
Email: rajanya.ghosh(at)nct-dresden.de