The NCT/UCC Research Group “Genetic Predisposition” focuses on the identification of disease causing germline variants/alterations in children with cancer with a special focus on acute leukemia of childhood, as well as the elucidation of the oncogenic capacity of these genetic variants in regard to environmental exposures.
Research Group Genetic Predisposition
Methodology
- Trio-sequencing of child-parent trios in children newly diagnosed with cancer
- Analysis of the sequencing data for known classical cancer predispositions and VUS
- Transfection, Transduction, Knockdown and Overexpression in cell systems
- CRISPR-Cas9 based technologies
- Protein biochemical methods (Western Blot, Immunoprecipitation, Reporter gene assays)
- Sequencing methods (NGS, Sanger-sequencing, Deep-Sequencing) (in cooperation)
- Transgenic mouse models
Team
Prof. Dr. Julia Hauer
Group Leader
Phone: +49 (0)351 458 3522
E-Mail: Julia.Hauer(at)uniklinikum-dresden.de
Carolin Melzig
Technical Assistant
Email: carolin.melzig(at)nct-dresden.de
Dr. Franziska Auer
Post-Doc
Phone: +49 (0)351 4179
E-Mail: Franziska.Auer(at)uniklinikum-dresden.de
Rajanya Ghosh
PhD Student
Email: rajanya.ghosh(at)nct-dresden.de
