Center for Evidence-Based Healthcare

The Center for Evidence-Based Healthcare (Zentrum für evidenzbasierte Gesundheitsversorgung - ZEGV) is an interdisciplinary institution of the University Hospital Carl Gustav Carus Dresden and the Medical Faculty Carl Gustav Carus of the Technical University Dresden. The primary aim of the ZEGV is to identify ways to improve the quality, effectiveness, efficiency and utility of medical interventions in routine care. Also, the goal is to enable the translation of latest research findings from basic research and clinical trials into routine care. The ZEGV also serves as an interdisciplinary platform to strengthen the fields of health services research, quality research and evidence-based medicine.

The scientists of the ZEGV are working in particular in the fields of oncology, pharmaceutical therapy and safety, health systems research as well as health services research with partners from various university hospital departments. Within these fields a broad variety of methods is being applied such as systematic reviews, outcomes research, quality and implementation research, assessment of patient preferences and shared decision making, organization and modelling of routine health care data as well as methods of health economics and health benefits assessment. To ensure high quality research based on the latest state of the art the ZEGV has a special focus on methods development and improvement. Through continuous teaching activities the methodologic expertise is passed on to medical and public health students of the medical faculty as well as students of other faculties of the TU Dresden.

In the field of oncology a working group has been established at the ZEGV constituting a close collaboration of the ZEGV, the NCT as well as the University Cancer Center (UCC, Comprehensive Cancer Center). The working group has a special focus on the assessment and application of patient-reported outcomes in routine care as well as the usage of various routine data sources including data linkage and data integration to provide answers on central questions within health services research.

Further information can be found at www.uniklinikum-dresden.de/de/das-klinikum/universitaetscentren/zegv.

Research activities of the Center for Evidence-based Healthcare @Zentrum für evidenzbasierte Gesundheitsversorgung (ZEGV)

Own recent publications

Schoffer, O., Roessler, M., Datzmann, T., Andreou, D., Jakob, J., Eichler, M., Richter, S., Schuler, M.K., Schmitt, J. Medical Care and Survival of Soft-Tissue and Bone Sarcoma Patients: Results and Methodological Aspects of a German Subnational Cohort Study Based on Administrative Healthcare Data. Oncol Res Treat, 2021. Online ahead of print. https://www.karger.com/Article/Abstract/513178

Reynolds, K. A., Schlessinger, D. I., Yanes, A. F., …, Schmitt, J., Kirkham, J. J., Poon, E., Sobanko, J. F., Cartee, T. V., Maher, I. A., Alam, M. Development of a Core Outcome Set for Cutaneous Squamous Cell Carcinoma Trials: Identification of Core Domains and Outcomes. The British journal of dermatology. 2021. Online ahead of print. https://onlinelibrary.wiley.com/doi/10.1111/bjd.19693

Schündeln, M. M., Lange, T., Knoll, M., Spix, C., Brenner, H., Bozorgmehr, K., Stock, C. Statistical methods for spatial cluster detection in childhood cancer incidence: A simulation study. Cancer epidemiology. 2021;70:101873. Online ahead of print. https://www.sciencedirect.com/science/article/abs/pii/S1877782120302071?via%3Dihub

Schündeln, M. M., Lange, T., Knoll, M., Spix, C., Brenner, H., Bozorgmehr, K., Stock, C. Methods of spatial cluster detection in rare childhood cancers: Benchmarking data and results from a simulation study on nephroblastoma. Data in Brief. 2021;34:106683. Online ahead of print. http://www.sciencedirect.com/science/article/pii/S2352340920315626

Eichler, M., Hentschel, L., Richter, S., Hohenberger, P., Kasper, B., Andreou, D., Pink, D., Jakob, J., Singer, S., Grützmann, R., Fung, S., Wardelmann, E., Arndt, K., Heidt, V., Hofbauer, C., Fried, M., Gaidzik, V.I., Verpoort, K., Ahrens, M., Weitz, J., Schaser, K.D., Bornhäuser, M., Schmitt, J., Schuler, M.K. The Health-Related Quality of Life of Sarcoma Patients and Survivors in Germany-Cross-Sectional Results of a Nationwide Observational Study (PROSa). Cancers (Basel), 2020. 12(12), 3590. https://www.mdpi.com/2072-6694/12/12/3590

Scheibe, M., Herrmann, A., Schmitt, J., Einhart, N., Sedlmayr, B., Kowalski, C. Implementation of patient-reported outcome assessment in routine cancer care: A systematic review of multicentric programs in Europe. Z Evid Fortbild Qual Gesundhwes, 2020. 156, 11-23. https://zefq-journal.com/article/S1865-9217(20)30134-3/fulltext

Bauer, A., Haufe, E., Heinrich, L., Seidler, A., Schulze, H.J., Elsner, P., Drexler, H., Letzel, S., John, S.M., Fartasch, M., Brüning, T., Dugas-Breit, S., Gina, M., Weistenhöfer, W., Bachmann, K., Bruhn, I., Lang, B.M., Brans, R., Allam, J.P., Grobe, W., Westerhausen, S., Knuschke, P., Wittlich, M., Diepgen, T.L., Schmitt, J. Basal cell carcinoma risk and solar UV exposure in occupationally relevant anatomic sites: do histological subtype, tumor localization and Fitzpatrick phototype play a role? A population-based case-control study. Journal of Occupational Medicine and Toxicology, 2020. 15(1): 28. https://occup-med.biomedcentral.com/articles/10.1186/s12995-020-00279-8

Hellmund, P., Schmitt, J., Roessler, M., Meier, F., Schoffer, O. Targeted and Checkpoint Inhibitor Therapy of Metastatic Malignant Melanoma in Germany, 2000-2016. Cancers (Basel), 2020. 12(9): 2354. https://www.mdpi.com/2072-6694/12/9/2354

Schoffer, O. Blickwinkel Versorgungsforschung: Effekte der Zertifizierung messbar? Im Fokus Onkologie. 2020;23(6):3-. https://www.springermedizin.de/blickwinkel-versorgungsforschung-effekte-der-zertifizierung-mess/18659208