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Center of Orthopedic and Trauma Surgery

Tumor research at the Center of Orthopedic and Trauma Surgery focusses on 2 areas: (I) Enhancing critical size bone defect regeneration in preclinical models and (II) Clinical studies on neoadjuvant therapy of bone and soft tissue sarcoma and a multicenter study on spine tumors.

(I) Bone defects in patients with bone tumors or metastatic bone disease require innovative therapies to support bone defect regeneration. We assessed whether sulfated hyaluronan included in collagen-based scaffold coatings can improve bone defect healing. Macroporous thermopolymerized lactide-based scaffolds were coated with collagen including non-sulfated or sulfated hyaluronan (HA/sHA3). At the tissue level, collagen/sHA3 promoted bone mineralization and decreased the amount of non-mineralized bone matrix. Moreover, collagen/sHA3-coated scaffolds bound more sclerostin in vivo. Binding assays confirmed a high binding affinity of sHA3 to sclerostin. Scaffolds coated with collagen/sHA3 represent a potentially suitable biomaterial to improve bone defect conditions in normal and compromised rats over 12 weeks. The underlying mechanism involves improved osteoblast function and binding sclerostin, a potent inhibitor of Wnt signaling and osteoblast function. 

(II) In a prospective clinical study, we investigated the prediction of the response to neoadjuvant polychemotherapy in bone and soft tissue sarcomas based on molecular expression profiles. In a multicenter study, we evaluated quality of life and outcomes after surgery of spinal tumors in children and adults.

Periacetabuläre extraartikuläre Beckenteilresektion bei hüftnahen Tumoren  (Enneking Typ IIb) und Rekonstruktion mit Beckenteilersatz (Sockelpfanne)
Schaser KD, Fritzsche H, Hofbauer C, Kleber C, Schwabe P, Günther KP
In: Meistertechniken in der operativen Orthopädie und Unfallchirurgie – Hüfte; Hrsg. Günther KP, Schaser KD (erscheint in 3/2021)

The Health-Related Quality of Life of Sarcoma Patients and Survivors in Germany-Cross-Sectional Results of a Nationwide Observational Study (PROSa). 
Eichler M, Hentschel L, Richter S, Hohenberger P, Kasper B, Andreou D, Pink D, Jakob J, Singer S, Grützmann R, Fung S, Wardelmann E, Arndt K, Heidt V, Hofbauer C, Fried M, Gaidzik VI, Verpoort K, Ahrens M, Weitz J, Schaser KD, Bornhäuser M, Schmitt J, Schuler MK, The PROSa Study Group.
Cancers (Basel). 2020 Nov 30;12(12):E3590.

[External fixator: temporary fixation and soft tissue management of the ankle]. 
Kamin K, Rammelt S, Kleber C, Marx C, Schaser KD.
Oper Orthop Traumatol. 2020 Oct;32(5):421-432. doi: 10.1007/s00064-020-00677-5

Characterization of Naturally Occurring Bioactive Factor Mixtures for Bone Regeneration. 
Bretschneider H, Quade M, Lode A, Gelinsky M, Rammelt S, Zwingenberger S, Schaser KD, Vater C.
Int J Mol Sci. 2020 Feb 19;21(4):1412.

[Complications and their management in orthopedic oncology]. 
Schaser KD, Günther KP.
Orthopade. 2020 Feb;49(2):85-87.

[Biopsy of musculoskeletal tumors : Complications and avoidable errors]. 
Winkler D, Fritzsche H, Schaser KD, Hofbauer C.
Orthopade. 2020 Feb;49(2):88-97

[Risk factors and management strategies for early and late infections following reconstruction with special tumour endoprostheses]. 
Janz V, Löchel J, Trampuz A, Schaser KD, Hofer A, Wassilew GI.
Orthopade. 2020 Feb;49(2):142-148

[Complication profile and revision concepts for megaprosthetic reconstruction following tumour resection at the hip]. 
Fritzsche H, Goronzy J, Schaser KD, Hofbauer C, Postler AE, Günther KP.
Orthopade. 2020 Feb;49(2):123-132

[Intraoperative and late complications after spinal tumour resection and dorsoventral reconstruction]. 
Thomas A, Hollstein T, Zwingenberger S, Schaser KD, Disch AC.
Orthopade. 2020 Feb;49(2):157-168.

Current surgical strategies for treating spinal tumors: Results of a questionnaire survey among members of the German Spine Society (DWG). 
Disch AC, Kleber C, Redemann D, Druschel C, Liljenqvist U, Schaser KD; Spine Tumor Group, Spine Section of the German Society for Orthopaedics and Trauma (DGOU).
Eur J Surg Oncol. 2020 Jan;46(1):89-94.

[Management of complications following tumor endoprosthetic replacement]. 
Fritzsche H, Hofbauer C, Winkler D, Günther KP, Goronzy J, Lützner J, Kisel W, Schaser KD.
Orthopade. 2019 Jul;48(7):588-597

Skelettmetastasen der Extremitäten – Management und operative Behandlungskonzepte
Walther JE, Fritzsche H, Hofbauer C, Schaser KD
Orthopädie und Unfallchirurgie up2date 2018; 13 (6): 611–627

Mechanobiologically optimized 3D titanium-mesh scaffolds enhance bone regeneration in critical segmental defects in sheep. 
Pobloth AM, Checa S, Razi H, Petersen A, Weaver JC, Schmidt-Bleek K, Windolf M, Tatai AÁ, Roth CP, Schaser KD, Duda GN, Schwabe P.
Sci Transl Med. 2018 Jan 10;10(423):

When does intraoperative 3D-imaging play a role in transpedicular C2 screw placement? 
Jacobs C, Roessler PP, Scheidt S, Plöger MM, Jacobs C, Disch AC, Schaser KD, Hartwig T.
Injury. 2017 Nov;48(11):2522-2528.

Behandlungsprinzipien von Tumoren am Fuß und Sprunggelenk
Fritzsche H, Schaser KD, Hofbauer C, Rammelt S
In: Rückfußchirurgie, Hrsg. Sabo D, Rammelt S: 107-124; 2017

Cardiac disease and advanced age increase the mortality risk following surgery for periprosthetic femoral fractures. 
Märdian S, Perka C, Schaser KD, Gruner J, Scheel F, Schwabe P.
Bone Joint J. 2017 Jul;99-B(7):921-926

Benign tumours and tumour-like lesions of the bone : General treatment principles]. 
Fritzsche H, Schaser KD, Hofbauer C.
Orthopade. 2017 Jun;46(6):484-497.

Fusions- und Korrekturtechniken an BWS und LWS – Spezielle Techniken
Schaser KD, Liljenqvist U, Knop C, Stücker R, Koller H, Meier O
In: Wirbelsäule interdisziplinär – Operative und konservative Therapie; Hrsg. Börm W, Meyer F, Bullmann V, Knop C: 524-563; 2017

Dorsale Instrumentation an BWS und LWS - Fixateur interne (offene Technik)
Schröder J, Disch A, Liljenqvist U, Schaser KD
In: Wirbelsäule interdisziplinär – Operative und konservative Therapie; Hrsg. Börm W, Meyer F, Bullmann V, Knop C: 492-494; 2017

Tumoren – Primäre Knochentumoren
Liljenqvist U, Schaser KD
In: Wirbelsäule interdisziplinär – Operative und konservative Therapie; Hrsg. Börm W, Meyer F, Bullmann V, Knop C: 251-254; 2017

[Consequences of the Foundation of a University Centre for Orthopaedics and Accident Surgery]. 
Schneiders W, Dittmann U, Hannemann F, Jäger M, Eberlein-Gonska M, Schaser KD, Zwipp H, Günther KP.
Z Orthop Unfall. 2016 Dec;154(6):629-635.

Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency. 
Kovac M, Blattmann C, Ribi S, Smida J, Mueller NS, Engert F, Castro-Giner F, Weischenfeldt J, Kovacova M, Krieg A, Andreou D, Tunn PU, Dürr HR, Rechl H, Schaser KD, Melcher I, Burdach S, Kulozik A, Specht K, Heinimann K, Fulda S, Bielack S, Jundt G, Tomlinson I, Korbel JO, Nathrath M, Baumhoer D.
Nat Commun. 2015 Dec 3;6:8940

Quantitative in vivo fusion assessment by (18)F-fluoride PET/CT following en bloc spondylectomy. 
Pumberger M, Prasad V, Druschel C, Disch AC, Brenner W, Schaser KD.
Eur Spine J. 2016 Mar;25(3):836-42

Skeletal metastatic disease of the femur: results by management with intramedullary nailing. 
Märdian S, Schaser KD, Ruppert M, Melcher I, Haas NP, Schwabe P.
Acta Chir Orthop Traumatol Cech. 2015;82(3):192-7.