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Department of Anesthesiology and Intensive Care Therapy

The Department of Anesthesiology and Intensive Care Therapy of the Carl Gustav Carus Faculty of Medicine at TU Dresden conducts research in all areas of our specialty, namely anesthesia, intensive care, pain therapy and critical emergency medicine, with a main focus on organ protection. The projects cover different aspects of medical investigation, from basic science up to clinical studies. 

Accordingly, our department investigates signaling pathways of cells to different patterns of stretch and degrees of shear stress, which may be present during artificial lung ventilation. Also, we conduct research in small and large animal models of organ failure, especially those mimicking acute pulmonary diseases, where several investigational tools for tissue imaging are applied, or even developed in our research facilities, for example computed tomography, positron emission tomography, electrical impedance tomography, optical coherence tomography and spectroscopy and multimodal imaging. 

Those methods are used for investigation of not only tissue structure and function, but also oncological changes of tissues. As part of a translational approach, findings are transported into clinical investigations and even therapy, whereby much of the research questions originate in the clinical activities of our department. In order to determine the potential of new developing, as well as already used therapeutic approaches for lung, kidney and brain protection, we perform several local and multicenter clinical trials. Last, but not least, we investigate effects of different intervention, including drugs, medical procedures and equipment on patient outcome, in order to provide physicians with evidence based recommendations.

Regional distribution of aeration, gas fraction (Fgas), perfusion and inflammation (KiP)

Anesthesiology 1

Fig. 1 - Regional distribution of aeration, gas fraction (Fgas), perfusion and inflammation (KiP) using combined computed and positron emission tomography during lung overdistension (volutrauma) and closing/reopening (atelectrauma) in a model of acute lung injury (from Güldner et al., Crit Care Med. 2016 Sep;44(9):e854-65)

Fig. 2 – Label-free analysis of a giant cell glioblastoma: Coherent Anti-Stokes Raman Scattering (CARS), two photon excited fluorescence (TPEF) and Second Harmonic Generation (SHG) show morphological tissue structures with high spatial resolution. (copyright: Roberta Galli, Ortrud Uckermann)

Comparative Effects of Volutrauma and Atelectrauma on Lung Inflammation in Experimental Acute Respiratory Distress Syndrome. Güldner A, Braune A, Ball L, Silva PL, Samary C, Insorsi A, Huhle R, Rentzsch I, Becker C, Oehme L, Andreeff M, Vidal Melo MF, Winkler T, Pelosi P, Rocco PR, Kotzerke J, Gama de Abreu M. Crit Care Med. 2016 Sep;44(9):e854-65.

Assessing the efficacy of coherent anti-Stokes Raman scattering microscopy for the detection of infiltrating glioblastoma in fresh brain samples. Galli R, Uckermann O, Temme A, Leipnitz E, Meinhardt M, Koch E, Schackert G, Steiner G, Kirsch M. J Biophotonics. 2017 early view, doi: 10.1002/jbio.201500323

High versus low positive end-expiratory pressure during general anaesthesia for open abdominal surgery (PROVHILO trial): a multicentre randomised controlled trial. PROVE Network Investigators for the Clinical Trial Network of the European Society of Anaesthesiology, Hemmes SN, Gama de Abreu M, Koch T, Pelosi P, Schultz MJ. Lancet. 2014 Aug 9;384(9942):495-503. doi: 10.1016/S0140-6736(14)60416-5.

Acute Lung Injury Causes Asynchronous Alveolar Ventilation That Can Be Corrected by Individual Sighs. Tabuchi A, Nickles HT, Kim M, Semple JW, Koch E, Brochard L, Slutsky AS, Pries AR, Kuebler WM. Am J Respir Crit Care Med. 2016 Feb 15;193(4):396-406

Effects of ultraprotective ventilation, extracorporeal carbon dioxide removal, and spontaneous breathing on lung morphofunction and inflammation in experimental severe acute respiratory distress syndrome. Güldner A, Kiss T, Bluth T, Uhlig C, Braune A, Carvalho N, Quast T, Rentzsch I, Huhle R, Spieth P, Richter T, Saddy F, Rocco PR, Kasper M, Koch T, Pelosi P, de Abreu MG.Anesthesiology. 2015 Mar;122(3):631-46.