Header Forschung

Department of Visceral, Thoracic and Vascular Surgery

Head: Jürgen Weitz

PIs: Christoph Kahlert, Adrian Seifert, Lena Seifert, Daniel E. Stange, Thilo Welsch

The Department of Visceral, Thoracic and Vascular Surgery at the University Hospital Dresden focusses on the surgical treatment of malignant diseases using open, minimally-invasive and robotic techniques. The clinical research covers many surgical and multimodal aspects of surgical oncology. Integration of robotics, navigation and virtual reality in surgical treatment of malignant diseases is a major focus of our clinical research. The translational research is focused on molecular and translational cancer research with the main interest on gastrointestinal, hepatobiliary and lung cancers.

The surgical translational research laboratory hosts the following groups:

  • The group of Christoph Kahlert performs research on exosomes for early detection of pancreatic cancers and their use in predicting the course of the disease.
  • The Seifert group focuses on new immuno-therapeutic approaches and the mechanisms of tumor-immune system interaction in gastro-intestinal tumors, specifically on the role of gamma-delta T-cells and the PD-1/PD-L1 axis.
  • The group of Daniel Stange uses 3D cancer models, so called tumor organoids, from mouse models and primary patient material to characterize therapy response in molecular subgroups of gastrointestinal cancers.
  • The group of Thilo Welsch is interested in the cytoskeletal and endosomal/autophagic mechanisms for tumor cell migration and metastasis, including 3-dimensional reconstruction and high-resolution fluorescence analysis as well as translational projects exploring the treatment response to surgery and chemotherapy, also considering genetic subtypes.

The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression. Seifert L, Werba G, Tiwari S, Giao Ly NN, Alothman S, Alqunaibit D, Avanzi A, Barilla R, Daley D, Greco SH, Torres-Hernandez A, Pergamo M, Ochi A, Zambirinis CP, Pansari M, Rendon M, Tippens D, Hundeyin M, Mani VR, Hajdu C, Engle D, Miller G. Nature. 2016 Apr 14;532(7598):245-9. 

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer. Melo SA*, Luecke LB*, Kahlert C*, Fernandez AF, Gammon ST, Kaye J, LeBleu VS, Mittendorf EA, Weitz J, Rahbari N, Reissfelder C, Pilarsky C, Fraga MF, Piwnica-Worms D, Kalluri R. Nature. 2015 Jul 9;523(7559):177-82.

Salinomycin inhibits growth of pancreatic cancer and cancer cell migration by disruption of actin stress fiber integrity. Schenk M, Aykut B, Teske C, Giese NA, Weitz J, Welsch T. Cancer Lett. 2015 Mar 28;358(2):161-9.

Immune escape and survival mechanisms in circulating tumor cells of colorectal cancer. Steinert G, Schölch S, Niemietz T, Iwata N, García SA, Behrens B, Voigt A, Kloor M, Benner A, Bork U, Rahbari NN, Büchler MW, Stoecklein NH, Weitz J, Koch M. Cancer Res. 2014 Mar 15;74(6):1694-704.

Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium. Stange DE, Koo BK, Huch M, Sibbel G, Basak O, Lyubimova A, Kujala P, Bartfeld S, Koster J, Geahlen JH, Peters PJ, van Es JH, van de Wetering M, Mills JC, Clevers H. Cell. 2013 Oct 10;155(2):357-68.