Institute for Clinical Chemistry und Laboratory Medicine (IKL)

The Institute for Clinical Chemistry und Laboratory Medicine (IKL) (director: Prof. Dr. T. Chavakis) performs centralized laboratory diagnostics for patient care as well as for clinical studies for the University Clinic, the Medical Faculty or cooperation partners. In addition, the IKL heads the „Dresden Integrated Liquid Biobank“ (DILB) for oncological research; DILB is an integrative part of the „Biobank Dresden“ (BBD). 

The IKL also performs exeperimental research, investigating the regulation of immune processes, including tumor immunology. The research projects focus on activation of cells of the innate immunity, on the bidirirectional interaction between inflammation and metabolism (immunometabolism) in the context of trained innate immunity and tumor immunology, on normal and malignant hematopoiesis (also in the context of the myelodysplastic syndrome), as well as on hypoxia-induced processes in inflammatory and malignant pathologies.

Neutrophils as Orchestrators in Tumor Development and Metastasis Formation.
Kalafati L, Mitroulis I, Verginis P, Chavakis T, Kourtzelis I.
Front Oncol. 2020 Dec 10;10:581457. Review.

Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity.
Kalafati L, Kourtzelis I, Schulte-Schrepping J, Li X, Hatzioannou A, Grinenko T, Hagag E, Sinha A, Has C, Dietz S, de Jesus Domingues AM, Nati M, Sormendi S, Neuwirth A, Chatzigeorgiou A, Ziogas A, Lesche M, Dahl A, Henry I, Subramanian P, Wielockx B, Murray P, Mirtschink P, Chung KJ, Schultze JL, Netea MG, Hajishengallis G, Verginis P, Mitroulis I, Chavakis
T. Cell. 2020 Oct 29;183(3):771-785.e12.

Regulation of the Bone Marrow Niche by Inflammation.
Mitroulis I, Kalafati L, Bornhäuser M, Hajishengallis G, Chavakis T.
Front Immunol. 2020 Jul 21;11:1540. 

Defining trained immunity and its role in health and disease.
Netea MG, Domínguez-Andrés J, Barreiro LB,Chavakis T, Divangahi M, Fuchs E, Joosten LAB, van der Meer JWM, Mhlanga MM, Mulder WJM, Riksen NP, Schlitzer A, Schultze JL, Stabell Benn C, Sun JC, Xavier RJ, Latz E.
Nat Rev Immunol. 2020 Jun;20(6):375-388.

An intrinsic role of IL-33 in Treg cell-mediated tumor immunoevasion.
Hatzioannou A, Banos A, Sakelaropoulos T, Fedonidis C, Vidali MS, Köhne M, Händler K, Boon L, Henriques A, Koliaraki V, Georgiadis P, Zoidakis J, Termentzi A, Beyer M,Chavakis T, Boumpas D, Tsirigos A, Verginis P. Nat Immunol. 2020 Jan;21(1):75-85.

Trained Innate Immunity and Its Implications for Mucosal Immunity and Inflammation.
Hajishengallis G, Li X, Mitroulis I, Chavakis T. Adv Exp Med Biol. 2019;1197:11-26. Review.

Hypoxia Pathway Proteins in Normal and Malignant Hematopoiesis
Ben Wielockx, Tatyana Grinenko, Peter Mirtschink, Triantafyllos Chavakis
Cells, .2019 Feb 13;8(2):155, Review

Defining trained immunity and its role in health and disease.
Netea MG, Domínguez-Andrés J, Barreiro LB,Chavakis T, Divangahi M, Fuchs E, Joosten LAB, van der Meer JWM, Mhlanga MM, Mulder WJM, Riksen NP, Schlitzer A, Schultze JL, Stabell Benn C, Sun JC, Xavier RJ, Latz E.
Nat Rev Immunol. 2020 Jun;20(6):375-388.

Regulation of the Bone Marrow Niche by Inflammation.
Mitroulis I, Kalafati L, Bornhäuser M, Hajishengallis G, Chavakis T.
Front Immunol. 2020 Jul 21;11:1540.