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Oral and Maxillofacial Surgery

At the Department of Oral and Maxillofacial Surgery, Dresden, the aim of oncological research is to individualize the operative tumor treatment in respect to tumor resection and to tissue reconstruction.  A prospective multicentric, interdisciplinary (Radiation Oncology, OMS, ENT) observation study has the primary objective of validating prognostic biomarkers for relapse-free survival 24 months after surgical treatment of early stage squamous cell carcinoma (UICC I and II) in the head and neck region. The biomarkers to be considered are currently explorative investigated in an ongoing retrospective study. Secondary objectives of this prospective, multicentric observation study are disease-free survival (2J-DFS), survival without distant metastases (2J-MFS) and overall survival (2J-OS) after 24 months, respectively. 

Another focus of oncological research is to elucidate gene related mechanisms in tumorigenesis. It is known that patients with Fanconi anemiea  (FA) gene mutations have a higher risk to HNSCC. As common feature we found a loss of heterozygosity in FA genes in 47% of our patients with HNSCC. 

In respect of reconstruction after ablative tumor surgery several prospective observation studies have been instigated, e.g. determining the use of prefabricated microvascular flaps for mandible reconstruction. The outcome of individual mandible implants is currently a focus of clinical research. In addition to allow for oral rehabilitation and reestablishing the chewing function the use of short dental implants is prospectively studied.

Oral Surgery1

Reconstruction of the mandible using a microvascular anastomosed fibula graft

Oral Surgery3

Prosthodontic rehabilitation in the lower jaw with fixed bridge on short dental implants (as seen on the left).

Bräuer C,  Lauer G, Leonhardt H
New method of alloplastic reconstruction of the mandible after subtotal mandibulectomy for medication-related osteonecrosis of the jaw.
Br J Oral Maxillofac Surg 2018 Jul;56(6):549-550. doi: 10.1016/j.bjoms.2018.04.004

Linge A, Schötz U, Löck S, Lohaus F, Neubeck C, Gudziol V, Nowak A, et al
Comparison of detection methods for HPV status as a prognostic marker for loco-regional control after radiochemotherapy in patients with HNSCC.
Radiother Oncol 127 (2018) 27-35

Löck S , Linge A, Seidlitz A, Bandurska-Luque A, Nowak A, Gudziol V, et al
Repeat FMISO-PET imaging weakly correlates with hypoxia-associated gene expressions for locally advanced HNSCC treated by primary radiochemotherapy
Radiother Oncol 2019 Jun; 135: 43-50. doi: 10.1016/j.radonc.2019.02.020.

Linge A, Schmidt S, Lohaus F, Krenn C, Bandurska-Luque A, Platzek I, Neubeck C, Appold S, Nowak A, et al
Independent validation of tumour volume, cancer stem cell markers and hypoxia-associated gene expressions for HNSCC after primary radiochemotherapy
Clin Transl Radiat Oncol, 2019 Mar 18;16:40-47. doi: 10.1016/j.ctro.2019.03.002

Schmidt S, Linge A, Grosser M, Lohaus F, Gudziol V, Nowak A, et al
Comparison of GeneChip, nCounter, and Real-Time PCR-Based Gene Expressions Predicting Locoregional Tumor Control after Primary and Postoperative Radiochemotherapy in Head and Neck Squamous Cell Carcinoma.
J Mol Diagn. 2020 Jun;22(6):801-810. doi: 10.1016/j.jmoldx.2020.03.005.