The Department for Translational Medical Oncology investigates the molecular and cellular mechanisms for cancer development, proliferation and evolution. The department engages in clinical as well as experimental activities to ensure a rapid turnaround of scientific results into clinical application and clinical outcome into new hypotheses. Experimentally, high-throughput, multi-parametric molecular profiling is used to discover differences in the genome of tumor and normal cells to identify novel targets for cancer therapy on the genomic or cellular level.
The group develops suitable model systems to functionally and mechanistically characterize their impact and assess the potential for clinical application. Clinically, a dedicated personalized oncology outpatient clinic provides consulting appointments to initiate innovative diagnostic approaches, and organizes a tumor board to discuss results of genetic tumor profiling and molecularly guided treatment strategies.