Wahjudi LW, Bernhardt S, Abnaof K, Horak P, Kreutzfeldt S, Heining C, Borgoni S, Becki C, Berg D, Richter D, Hutter B, Uhrig S, Pfütze K, Leichsenring J, Glimm H, Brors B, von Kalle C, Stenzinger A, Korf U, Fröhling S, Wiemann S. Integrating proteomics into precision oncology. Int J Cancer. 2020 Sep 19. doi: 10.1002/ijc.33301. Online ahead of print
Laskin J, Liu SV, Tolba K, Heining C, Schlenk RF, Cheema P, Cadranel J, Jones MR, Drilon A, Cseh A, Gyorffy S, Solca F, Duruisseaux M. NRG1 fusion-driven tumors: biology, detection and the therapeutic role of afatinib and other ErbB-targeting agents. Ann Oncol. 2020 doi: 0.1016/j.annonc.2020.08.2335. Online ahead of print.
Cadranel J, Liu SV, Duruisseaux M, Branden E, Goto Y, Weinberg BA, Heining C, Schlenk RF, Cheema P, Jones MR, Drilon A, Trombetta D, Muscarella LA, Tolba K, Gounant V, Cseh A, Solca F, Laskin JJ, Renouf DJ. Therapeutic Potential of Afatinib in NRG1 Fusion-Driven Solid Tumors: A Case Series. Oncologist. 2020 Aug 27. doi: 10.163. Online ahead of print
Heilig CE, Horak P, Lipka DB, Mock A, Uhrig S, Kreutzfeldt S, Richter S, Gieldon L, Fröhlich M, Hutter B, Hübschmann D, Teleanu V, Schmier JW, Philipzen J, Beuthien-Baumann B, Schröck E, von Deimling A, Bauer S, Heining C, Mechtersheimer G, Stenzinger A, Brors B, Wardelmann E, Glimm H, Hartmann W, Fröhling S. Germline SDHB-inactivating mutation in gastric spindle cell sarcoma. Genes Chromosomes Cancer. 2020 Oct;59(10):601-608. doi: 10.1002/gcc.22876. Epub 2020 Jun 26.
Möhrmann, L.; Zowada, M. K.; Strakerjahn, H.; et al. A Perivascular Niche in the Bone Marrow Hosts Quiescent and Proliferating Tumorigenic Colorectal Cancer Cells. Int. J. Cancer 2020. https://doi.org/10.1002/ijc.32933.
Voronina, N.; Wong, J. K. L.; Hübschmann, D.; et al. The Landscape of Chromothripsis across Adult Cancer Types. Nat Commun 2020, 11 (1), 2320. https://doi.org/10.1038/s41467-020-16134-7.
Horak, P.; Uhrig, S.; Witzel, M.; et al. Comprehensive Genomic Characterization of Gene Therapy-Induced T-Cell Acute Lymphoblastic Leukemia. Leukemia 2020. https://doi.org/10.1038/s41375-020-0779-z.
Ronellenfitsch, M. W.; Harter, P. N.; Kirchner, M.; et al. Targetable ERBB2 Mutations Identified in Neurofibroma/Schwannoma Hybrid Nerve Sheath Tumors. J. Clin. Invest. 2020. https://doi.org/10.1172/JCI130787.
Weinberg, F.; Griffin, R.; Fröhlich, M.; et al. Identification and Characterization of a BRAF Fusion Oncoprotein with Retained Autoinhibitory Domains. Oncogene 2019. https://doi.org/10.1038/s41388-019-1021-1.
Tirier, S. M.; Park, J.; Preußer, F; et al. Pheno-Seq - Linking Visual Features and Gene Expression in 3D Cell Culture Systems. Sci Rep 2019, 9 (1), 12367. https://doi.org/10.1038/s41598-019-48771-4.
Gröschel, S.; Hübschmann, D.; Raimondi, F.; et al. Defective Homologous Recombination DNA Repair as Therapeutic Target in Advanced Chordoma. Nat Commun 2019, 10 (1), 1635. https://doi.org/10.1038/s41467-019-09633-9.
Wünsche, P.; Eckert, E. S. P.; Holland-Letz, T.; et al. Mapping Active Gene-Regulatory Regions in Human Repopulating Long-Term HSCs. Cell Stem Cell 2018, 23 (1), 132-146.e9. https://doi.org/10.1016/j.stem.2018.06.003.
Heining, C.; Horak, P.; Uhrig, S.; et al. NRG1 Fusions in KRAS Wild-Type Pancreatic Cancer. Cancer Discov 2018, 8 (9), 1087–1095. https://doi.org/10.1158/2159-8290.CD-18-0036.
Bormann, F.; Rodríguez-Paredes, M.; Lasitschka, F.; et al. Cell-of-Origin DNA Methylation Signatures Are Maintained during Colorectal Carcinogenesis. Cell Rep 2018, 23 (11), 3407–3418. https://doi.org/10.1016/j.celrep.2018.05.045.
Perera-Bel, J.; Hutter, B.; Heining, C.; et al. From Somatic Variants towards Precision Oncology: Evidence-Driven Reporting of Treatment Options in Molecular Tumor Boards. Genome Med 2018, 10 (1), 18. https://doi.org/10.1186/s13073-018-0529-2.
Giessler, K. M.; Kleinheinz, K.; Huebschmann, D.; et al. Genetic Subclone Architecture of Tumor Clone-Initiating Cells in Colorectal Cancer. J. Exp. Med. 2017, 214 (7), 2073–2088. https://doi.org/10.1084/jem.20162017.
Dieter, S. M.; Glimm, H.; Ball, C. R. Colorectal Cancer-Initiating Cells Caught in the Act. EMBO Mol. Med. 2017, 9 (7), 856–858. https://doi.org/10.15252/emmm.201707858.
Horak, P.; Klink, B.; Heining, C.; et al. Precision Oncology Based on Omics Data: The NCT Heidelberg Experience. Int. J. Cancer 2017, 141 (5), 877–886. https://doi.org/10.1002/ijc.30828.
Ball, C. R.; Oppel, F.; Ehrenberg, K. R.; et al. Succession of Transiently Active Tumor-Initiating Cell Clones in Human Pancreatic Cancer Xenografts. EMBO Mol Med 2017, 9 (7), 918–932. https://doi.org/10.15252/emmm.201607354.
Dieter, S. M.; Giessler, K. M.; Kriegsmann, M.; et al. Patient-Derived Xenografts of Gastrointestinal Cancers Are Susceptible to Rapid and Delayed B-Lymphoproliferation. Int. J. Cancer 2017, 140 (6), 1356–1363. https://doi.org/10.1002/ijc.30561.
Weischenfeldt, J.; Dubash, T.; Drainas, A. P.; et al. Pan-Cancer Analysis of Somatic Copy-Number Alterations Implicates IRS4 and IGF2 in Enhancer Hijacking. Nat. Genet. 2017, 49 (1), 65–74. https://doi.org/10.1038/ng.3722.
Dubash, T. D.; Hoffmann, C. M.; Oppel, F.; et al. Phenotypic Differentiation Does Not Affect Tumorigenicity of Primary Human Colon Cancer Initiating Cells. Cancer Lett. 2016, 371 (2), 326–333. https://doi.org/10.1016/j.canlet.2015.11.037.
Horak, P.; Fröhling, S.; Glimm, H. Integrating Next-Generation Sequencing into Clinical Oncology: Strategies, Promises and Pitfalls. ESMO Open 2016, 1 (5), e000094. https://doi.org/10.1136/esmoopen-2016-000094.