The research program aims to (1) create new diagnostic and therapeutic options for children with cancer, (2) to develop new tumor classification systems based on innovative diagnostics and (3) to unravel mechanisms of tumorigenesis and to develop biomarker driven international combination early phase clinical trials.
Research Profile Dresden
The Pediatric Oncology Program started its activity in 2019 at the medical campus Carl Gustav Carus TU Dresden. Understanding the genetic predisposition in childhood cancer with a focus on acute leukemia is intended and genetic predisposition is considered essential for disease evolution, therapy response and especially for toxicity and late effects. Thus, a clinical program (“TRIOstudy”) is set up offering exome sequencing of germline to all newly diagnosed children, including their parents at the pediatric oncology service at TU Dresden. In addition, the role of immune modulation and exposure to infection in children with acute leukemia is investigated, aiming for the prevention of the most common cancer of childhood.