NCT MASTER

.“Precision oncology” describes the ability to predict which patients will likely respond to specific cancer therapies based on comprehensive, high-resolution molecular diagnostics as well as the functional understanding of individual tumors. Such stratification of patients can be achieved, e.g., through next-generation sequencing of tumor DNA and RNA, revealing genomic alterations that have immediate clinical implications. DKFZ/NCT/DKTK MASTER provides a complete workflow for selection and consenting of patients, tissue processing, whole-exome/genome and RNA sequencing, bioinformatic analysis, and molecularly guided clinical decision making by molecular tumor boards, which are held three times a week and include members with expertise in clinical oncology, pathology, molecular biology, bioinformatics, and medical genetics and counseling. Since many molecular alterations identified in human cancers have unknown functional consequences and can therefore not directly be interpreted regarding their suitability as therapeutic targets, separating “driver” mutations from biologically neutral “passenger” alterations is critical for translating genetic information into the clinic. Furthermore, the therapeutic value of known oncogenic mutations may vary depending on tissue context. To address these challenges, we investigate the functional role of genetic alterations predicted to be damaging in appropriate experimental systems, followed by the analysis of phenotypic consequences. The goal of these studies is to establish a versatile platform for rapid “functionalization” of individual molecular profiles and develop a continuously evolving, “learning” system to support treatment decisions at NCT.

“Precision oncology” describes the ability to predict which patients will likely respond to specific cancer therapies based on comprehensive, high-resolution molecular diagnostics as well as the functional understanding of individual tumors. Such stratification of patients can be achieved, e.g., through next-generation sequencing of tumor DNA and RNA, revealing genomic alterations that have immediate clinical implications. DKFZ/NCT/DKTK MASTER provides a complete workflow for selection and consenting of patients, tissue processing, whole-exome/genome and RNA sequencing, bioinformatic analysis, and molecularly guided clinical decision making by molecular tumor boards, which are held three times a week and include members with expertise in clinical oncology, pathology, molecular biology, bioinformatics, and medical genetics and counseling. Since many molecular alterations identified in human cancers have unknown functional consequences and can therefore not directly be interpreted regarding their suitability as therapeutic targets, separating “driver” mutations from biologically neutral “passenger” alterations is critical for translating genetic information into the clinic. Furthermore, the therapeutic value of known oncogenic mutations may vary depending on tissue context. To address these challenges, we investigate the functional role of genetic alterations predicted to be damaging in appropriate experimental systems, followed by the analysis of phenotypic consequences. The goal of these studies is to establish a versatile platform for rapid “functionalization” of individual molecular profiles and develop a continuously evolving, “learning” system to support treatment decisions at NCT.

{ "short_title": "NCT MASTER", "data_mode": "900", "data_mode_number": "000001186", "official_title": "K\u00f6rpermaterialstudie: NCT-MASTER Platform Molecularly aided stratification for tumor eradication research", "accrual_state": "running", "therapeutic_value": "nonTherapeutic", "therapieansatz_value": "not_applicable", "therapieintervention_value": "not_applicable", "therapielinie_value": "not_applicable", "ctgov_number": null, "eudract_number": null, "general_contact_email": "master-dresden@nct-dresden.de", "general_contact_phone": "+49 351-5541", "hauptpruefer_dd_name": "Prof. Dr. med. Hanno Glimm", "description_laie_de": "Hauptziele dieser Studie sind die Analyse der genetischen, epigenetischen, proteomischen Ver\u00e4nderungen in individuellen Tumorgeweben sowie die Analytik der \r\nzellul\u00e4ren Zusammensetzung. Dies dient der Generierung von Hypothesen zum intelligenten Einsatz neuer zielgerichteter Tumortherapieverfahren, welche spezifisch nur auf die im Tumor nachgewiesenen molekularen Ver\u00e4nderungen ausgerichtet sind und damit eine h\u00f6here therapeutische Wirksamkeit bei gleichzeitig geringeren Nebenwirkungen erm\u00f6glichen k\u00f6nnen.", "description_laie_en": "\u201cPrecision oncology\u201d describes the ability to predict which patients will likely respond to specific cancer therapies based on comprehensive, high-resolution molecular diagnostics as well as the functional understanding of individual tumors.\r\n\r\nSuch stratification of patients can be achieved, e.g., through next-generation sequencing of tumor DNA and RNA, revealing genomic alterations that have immediate clinical implications. DKFZ/NCT/DKTK MASTER provides a complete workflow for selection and consenting of patients, tissue processing, whole-exome/genome and RNA sequencing, bioinformatic analysis, and molecularly guided clinical decision making by molecular tumor boards, which are held three times a week and include members with expertise in clinical oncology, pathology, molecular biology, bioinformatics, and medical genetics and counseling.\r\n\r\nSince many molecular alterations identified in human cancers have unknown functional consequences and can therefore not directly be interpreted regarding their suitability as therapeutic targets, separating \u201cdriver\u201d mutations from biologically neutral \u201cpassenger\u201d alterations is critical for translating genetic information into the clinic. Furthermore, the therapeutic value of known oncogenic mutations may vary depending on tissue context. To address these challenges, we investigate the functional role of genetic alterations predicted to be damaging in appropriate experimental systems, followed by the analysis of phenotypic consequences. The goal of these studies is to establish a versatile platform for rapid \u201cfunctionalization\u201d of individual molecular profiles and develop a continuously evolving, \u201clearning\u201d system to support treatment decisions at NCT.", "description_expert_de": "Hauptziele dieser Studie sind die Analyse der genetischen, epigenetischen, proteomischen Ver\u00e4nderungen in individuellen Tumorgeweben sowie die Analytik der \r\nzellul\u00e4ren Zusammensetzung. Dies dient der Generierung von Hypothesen zum intelligenten Einsatz neuer zielgerichteter Tumortherapieverfahren, welche spezifisch nur auf die im Tumor nachgewiesenen molekularen Ver\u00e4nderungen ausgerichtet sind und damit eine h\u00f6here therapeutische Wirksamkeit bei gleichzeitig geringeren Nebenwirkungen erm\u00f6glichen k\u00f6nnen.", "description_expert_en": ".\u201cPrecision oncology\u201d describes the ability to predict which patients will likely respond to specific cancer therapies based on comprehensive, high-resolution molecular diagnostics as well as the functional understanding of individual tumors.\r\n\r\nSuch stratification of patients can be achieved, e.g., through next-generation sequencing of tumor DNA and RNA, revealing genomic alterations that have immediate clinical implications. DKFZ/NCT/DKTK MASTER provides a complete workflow for selection and consenting of patients, tissue processing, whole-exome/genome and RNA sequencing, bioinformatic analysis, and molecularly guided clinical decision making by molecular tumor boards, which are held three times a week and include members with expertise in clinical oncology, pathology, molecular biology, bioinformatics, and medical genetics and counseling.\r\n\r\nSince many molecular alterations identified in human cancers have unknown functional consequences and can therefore not directly be interpreted regarding their suitability as therapeutic targets, separating \u201cdriver\u201d mutations from biologically neutral \u201cpassenger\u201d alterations is critical for translating genetic information into the clinic. Furthermore, the therapeutic value of known oncogenic mutations may vary depending on tissue context. To address these challenges, we investigate the functional role of genetic alterations predicted to be damaging in appropriate experimental systems, followed by the analysis of phenotypic consequences. The goal of these studies is to establish a versatile platform for rapid \u201cfunctionalization\u201d of individual molecular profiles and develop a continuously evolving, \u201clearning\u201d system to support treatment decisions at NCT.", "rechtsgrundlage_value": "BO", "phase_amg_value": null, "main_cat_id": 9, "sub_cat_id": 46 }

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