TREAT ctDNA

Gynecological tumors / Breast cancer
Breast cancer
First-Line-Therapy (Metastatic Disease/Hematology)
The study investigates whether treatment with elacestrant (an oral selective estrogen receptor degrader: SERD) leads to better treatment outcomes compared to standard antihormonal therapy. During the ctDNA screening phase, patient blood samples are regularly tested for circulating tumor DNA (ctDNA, so-called liquid biopsy). If ctDNA is detected, patients without evidence of distant metastases receive antihormonal therapy. This is a randomized study. Patients receive either elacestrant (oral) or standard antihormonal therapy
The study investigates whether treatment with elacestrant (an oral selective estrogen receptor degrader: SERD) leads to better treatment outcomes compared to standard antihormonal therapy. During the ctDNA screening phase, patient blood samples are regularly tested for circulating tumor DNA (ctDNA, so-called liquid biopsy). If ctDNA is detected, patients without evidence of distant metastases receive antihormonal therapy. This is a randomized study. Patients receive either elacestrant (oral) or standard antihormonal therapy