ELBE-Pro-Kids

Section NCT
Category Pediatric oncology/hematology
Subcategory CNS tumors
Trial Type Radiotherapy Studies
Description for experts In the present study, the short and medium-term consequences of proton therapy on cognitive processes are to be highlighted. In a second step, these findings will be compared with a group of children and adolescents who did not receive radiotherapy as part of their curative brain tumor therapy (surgical therapy alone) and with a healthy control group. In this way, the extent to which these treatment options differ in terms of their short and medium-term consequences will be determined. Brain research approaches are used that make it possible to visualize even small changes in mental performance. This means that treatment effects can be easily recorded and thus improve the treatment of children and adolescents with brain tumors in the future.
Description for laymen
JSON Data { "short_title": "ELBE-Pro-Kids", "data_mode": "900", "data_mode_number": "000001335", "official_title": "Hirnleistungsf\u00e4higkeit nach Protonentherapie bei Kindern und Jugendlichen. Eine longitudinale Bewertung der kurz- und mittelfristigen Effekte der Protonen-Strahlentherapie im Vergleich zu nicht bestrahlten Kindern auf die kognitiven Prozesse bei Kindern und Jugendlichen mit Hirntumoren", "accrual_state": "running", "therapeutic_value": "nonTherapeutic", "therapieansatz_value": null, "therapieintervention_value": null, "therapielinie_value": null, "ctgov_number": "NCT04066465", "eudract_number": null, "general_contact_email": "str.studien@uniklinikum-dresden.de", "general_contact_phone": "+49 351-4582238", "hauptpruefer_dd_name": "Prof Dr. med. Mechthild Krause", "description_laie_de": "In der vorliegenden Studie sollen die kurz- und mittelfristigen Folgen einer Protonentherapie auf kognitive Prozesse herausgestellt werden. In einem zweiten Schritt sollen diese Befunde mit einer Gruppe von Kindern und Jugendlichen verglichen werden, die im Rahmen ihrer kurativen Hirntumor-Therapie keine Strahlentherapie erhalten haben (alleinige operative Therapie) sowie mit einer gesunden Kontrollgruppe. Somit wird erfasst, inwieweit sich diese Behandlungsm\u00f6glichkeiten hinsichtlich ihrer kurz- und mittelfristigen Folgen unterscheiden. Dabei werden Ans\u00e4tze der Hirnforschung verwendet, die es erm\u00f6glichen, bereits kleine Ver\u00e4nderungen in den geistigen Leistungen sichtbar zu machen. Somit k\u00f6nnen Behandlungseffekte gut erfasst werden und dadurch zuk\u00fcnftig die Behandlung von Kindern und Jugendlichen mit Hirntumoren verbessert werden.", "description_laie_en": null, "description_expert_de": null, "description_expert_en": "In the present study, the short and medium-term consequences of proton therapy on cognitive processes are to be highlighted. In a second step, these findings will be compared with a group of children and adolescents who did not receive radiotherapy as part of their curative brain tumor therapy (surgical therapy alone) and with a healthy control group. In this way, the extent to which these treatment options differ in terms of their short and medium-term consequences will be determined. Brain research approaches are used that make it possible to visualize even small changes in mental performance. This means that treatment effects can be easily recorded and thus improve the treatment of children and adolescents with brain tumors in the future.", "rechtsgrundlage_value": "BO", "phase_amg_value": null, "main_cat_id": 14, "sub_cat_id": 62 }
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Short name 900-000001335