The aim of this scientific investigation is to find biological factors (biomarkers) that allow the efficacy of radiochemotherapy and the course of the disease to be predicted. This means that the tumour cells are taken in cell culture and then exposed to the same treatment that you are receiving. In the end, the response of your tumour in the body will be compared with that of the tumour in cell culture. In addition, components of the tumour such as proteins, the genetic material (genes, sections on the DNA) and the carriers of genetic information (RNA molecules) are examined using laboratory methods in order to be able to determine more reliably in future whether a tumour will reappear or not.