Trial Type
First-Line-Therapy (Metastatic Disease/Hematology)
Description for experts
This is an international, multicenter, randomized, open, Phase III trial to evaluate theefficacy and safety of carboplatin/paclitaxel/bevacizumab followed by bevacizumab andniraparib compared to carboplatin/paclitaxel followed by niraparib in patients with newlydiagnosed advanced ovarian cancer.
Description for laymen
This is an international, multicenter, randomized, open, Phase III trial to evaluate theefficacy and safety of carboplatin/paclitaxel/bevacizumab followed by bevacizumab andniraparib compared to carboplatin/paclitaxel followed by niraparib in patients with newlydiagnosed advanced ovarian cancer.
JSON Data
{
"short_title": "AGO-Ovar 28",
"data_mode": "900",
"data_mode_number": "000002361",
"official_title": "Niraparib vs Niraparib in Combination With Bevacizumab in Patients With Carboplatinum-taxane Based Chemotherapy in Advanced Ovarian Cancer (A Multicentre Randomised Phase III Trial)",
"accrual_state": "running",
"therapeutic_value": "therapeutic",
"therapieansatz_value": "palliativ",
"therapieintervention_value": "neoadjuvant",
"therapielinie_value": "first",
"ctgov_number": "NCT05009082",
"eudract_number": "2021-001271-16",
"general_contact_email": "studiensekretariat.gyn@ukdd.de",
"general_contact_phone": "+49 351-4584202",
"hauptpruefer_dd_name": "Prof. Dr. med. Pauline Wimberger",
"description_laie_de": "Hierbei handelt es sich um eine internationale, multizentrische, randomisierte, offene Phase-III-Studie zur Bewertung der Wirksamkeit und Sicherheit von Carboplatin/Paclitaxel/Bevacizumab gefolgt von Bevacizumab und Niraparib im Vergleich zu Carboplatin/Paclitaxel gefolgt von Niraparib bei Patienten mit neu diagnostiziertem fortgeschrittenem Eierstockkrebs.",
"description_laie_en": "This is an international, multicenter, randomized, open, Phase III trial to evaluate theefficacy and safety of carboplatin/paclitaxel/bevacizumab followed by bevacizumab andniraparib compared to carboplatin/paclitaxel followed by niraparib in patients with newlydiagnosed advanced ovarian cancer.",
"description_expert_de": "Hierbei handelt es sich um eine internationale, multizentrische, randomisierte, offene Phase-III-Studie zur Bewertung der Wirksamkeit und Sicherheit von Carboplatin/Paclitaxel/Bevacizumab gefolgt von Bevacizumab und Niraparib im Vergleich zu Carboplatin/Paclitaxel gefolgt von Niraparib bei Patienten mit neu diagnostiziertem fortgeschrittenem Eierstockkrebs.",
"description_expert_en": "This is an international, multicenter, randomized, open, Phase III trial to evaluate theefficacy and safety of carboplatin/paclitaxel/bevacizumab followed by bevacizumab andniraparib compared to carboplatin/paclitaxel followed by niraparib in patients with newlydiagnosed advanced ovarian cancer.",
"rechtsgrundlage_value": "AMG",
"phase_amg_value": "III",
"main_cat_id": 3,
"sub_cat_id": 15
}
