KPS-Register

Section NCT
Category Preventiv
Subcategory General
Trial Type Register and supportive Studies
Description for experts Over 50 hereditary diseases are known to be associated with an increased risk of cancer. For many of these diseases, little is known about the specific cancer risk. For some diseases, it seems to make sense to carry out early detection tests due to the high risk of cancer. However, little is known about the benefits of these examinations. In addition, the hereditary basis of cancer development and the changes in the tumour cells of those affected have not yet been sufficiently researched. It can be assumed that a significant proportion of all patients with cancer develop it due to a genetic predisposition. There are various unanswered questions for patients with cancer predisposition syndromes: What is the benefit of expert-recommended screening? Are there genotype-phenotype correlations? How high are the cancer risks in different age groups? What is the prognosis of cancer in patients with a genetic predisposition to cancer? What particular side effects of therapy occur? How can the treatment of people with a cancer predisposition be improved? What are the biological processes that lead to the development of cancer?
Description for laymen
JSON Data { "short_title": "KPS-Register", "data_mode": "900", "data_mode_number": "000002466", "official_title": "Krebspr\u00e4dispositionssyndrom-Register 01", "accrual_state": "running", "therapeutic_value": "nonTherapeutic", "therapieansatz_value": null, "therapieintervention_value": null, "therapielinie_value": null, "ctgov_number": null, "eudract_number": null, "general_contact_email": "Kik-dokuteam-hs65@ukdd.de", "general_contact_phone": "+49 351-4585035", "hauptpruefer_dd_name": "Tobias D\u00e4britz", "description_laie_de": "\u00dcber 50 erbliche Erkrankungen gehen bekannterweise mit einem erh\u00f6hten Krebsrisiko einher. Bei vielen dieser Erkrankungen ist wenig \u00fcber das konkrete Krebsrisiko bekannt. Bei einigen Erkrankungen scheint es aufgrund des hohen Krebsrisikos sinnvoll zu sein, Fr\u00fcherkennungsuntersuchungen durchzuf\u00fchren. \u00dcber den Nutzen dieser Untersuchungen ist allerdings wenig bekannt. Zudem sind erbliche Grundlagen der Krebsentstehung und die Ver\u00e4nderungen in den Tumorzellen Betroffener bisher unzureichend erforscht.\r\n\r\nEs ist davon auszugehen, dass ein signifikanter Anteil aller Patienten mit einer Krebserkrankung diese aufgrund einer genetischen Veranlagung entwickelt. F\u00fcr Patienten mit Krebspr\u00e4dispositionssyndromen bestehen diverse offene Fragen:\r\n\r\nWas ist der Nutzen der von Experten empfohlenen Fr\u00fcherkennung?\r\nGibt es Genotyp-Ph\u00e4notyp Korrelationen?\r\nWie hoch sind die Krebsrisiken in unterschiedlichen Altersbereichen?\r\nWie ist die Prognose von Krebserkrankungen bei Patienten mit einer genetischen Krebspr\u00e4disposition?\r\nWelche besonderen Therapienebenwirkungen treten auf?\r\nWie kann man die Therapie von Menschen mit einer Krebspr\u00e4disposition verbessern?\r\nWas sind die biologischen Prozesse, die zu der Krebsentstehung f\u00fchren?", "description_laie_en": null, "description_expert_de": null, "description_expert_en": "Over 50 hereditary diseases are known to be associated with an increased risk of cancer. For many of these diseases, little is known about the specific cancer risk. For some diseases, it seems to make sense to carry out early detection tests due to the high risk of cancer. However, little is known about the benefits of these examinations. In addition, the hereditary basis of cancer development and the changes in the tumour cells of those affected have not yet been sufficiently researched.\r\n\r\nIt can be assumed that a significant proportion of all patients with cancer develop it due to a genetic predisposition. There are various unanswered questions for patients with cancer predisposition syndromes:\r\n\r\nWhat is the benefit of expert-recommended screening?\r\nAre there genotype-phenotype correlations?\r\nHow high are the cancer risks in different age groups?\r\nWhat is the prognosis of cancer in patients with a genetic predisposition to cancer?\r\nWhat particular side effects of therapy occur?\r\nHow can the treatment of people with a cancer predisposition be improved?\r\nWhat are the biological processes that lead to the development of cancer?", "rechtsgrundlage_value": "BO", "phase_amg_value": null, "main_cat_id": 13, "sub_cat_id": 61 }
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Short name 900-000002466