MNP Int R

Pediatric oncology/hematology
CNS tumors
Register and supportive Studies
The constantly growing diversity of CNS tumour types in childhood and adolescence is reflected in extremely different disease progressions, and the rarity of individual tumour types and their varying appearances often make diagnosis difficult. However, the correct classification of CNS tumours is of paramount importance for the selection of the optimal treatment strategy for each patient. In order to increase diagnostic accuracy and thereby support accurate classification, MNP Int R will investigate CNS tumours at the time of initial diagnosis using molecular genetic analysis methods. Primary objectives Establishment of comprehensive molecular diagnostics Establishment of an international register for molecular diagnostic data Integration of neuropathological reference diagnosis, radiological reference findings and molecular genetic results in a multi-layered diagnosis Further development of DNA methylation-based CNS tumour classification Correlation of molecular diagnostic parameters with clinical disease progression Analysing the collected data Provision of data and assistance in the interpretation of molecular genetic information for clinicians, patients and their parents, as well as scientists