Over 50 hereditary diseases are known to be associated with an increased risk of cancer. For many of these diseases, little is known about the specific cancer risk. For some diseases, it seems to make sense to carry out early detection tests due to the high risk of cancer. However, little is known about the benefits of these examinations. In addition, the hereditary basis of cancer development and the changes in the tumour cells of those affected have not yet been sufficiently researched.
It can be assumed that a significant proportion of all patients with cancer develop it due to a genetic predisposition. There are various unanswered questions for patients with cancer predisposition syndromes:
What is the benefit of expert-recommended screening?
Are there genotype-phenotype correlations?
How high are the cancer risks in different age groups?
What is the prognosis of cancer in patients with a genetic predisposition to cancer?
What particular side effects of therapy occur?
How can the treatment of people with a cancer predisposition be improved?
What are the biological processes that lead to the development of cancer?
