EORTC QoL Thresholds

Gynecological tumors / Breast cancer
Ovarian cancer, Endometrial cancer
Register and supportive Studies
Background: Patient-reported outcomes (PROs) are often difficult to interpret for untrained persons. For their use in routine clinical practice, thresholds are needed that simplify the interpretation of the results for users. For one of the world's most frequently used PRO-instruments in the field of oncology (the EORTC QLQ-C30), such threshold values were determined in a previous research project in relation to the clinical significance of the information collected. Such thresholds are not yet available for the entity-specific supplementary modules of the QLQ C30. Objective: To determine thresholds for the clinical importance of PROs for entity-specific EORTC questionnaires. Approach: Questionnaire study. The symptoms/functional limitations of patients and so-called anchor items that record the clinical significance of the symptoms/functional limitations are collected. Conclusion: Threshold values for the clinical significance of a total of 8 EORTC questionnaire modules will be developed. The University Hospital Dresden is involved in determining the threshold values for the QLQ-EN24 (endometrium) and the QLQ-OV28 (ovarian cancer).
Background: Patient-reported outcomes (PROs) are often difficult to interpret for untrained persons. For their use in routine clinical practice, thresholds are needed that simplify the interpretation of the results for users. For one of the world's most frequently used PRO-instruments in the field of oncology (the EORTC QLQ-C30), such threshold values were determined in a previous research project in relation to the clinical significance of the information collected. Such thresholds are not yet available for the entity-specific supplementary modules of the QLQ C30. Objective: To determine thresholds for the clinical importance of PROs for entity-specific EORTC questionnaires. Approach: Questionnaire study. The symptoms/functional limitations of patients and so-called anchor items that record the clinical significance of the symptoms/functional limitations are collected. Conclusion: Threshold values for the clinical significance of a total of 8 EORTC questionnaire modules will be developed. The University Hospital Dresden is involved in determining the threshold values for the QLQ-EN24 (endometrium) and the QLQ-OV28 (ovarian cancer).