The primary objective of this study is to investigate if intensified chemotherapy followed by consolidating high-dose chemotherapy and autologous stem-cell transplantation (HDTASCT) is superior to conventional chemotherapy with R-MP followed by maintenance in
elderly patients with newly diagnosed PCNSL regarding 1-year progression free survival (PFS). Secondary objectives are the investigation of quality of life, remission after treatment, event free survival, overall survival (OS) and treatment related morbidities (neurotoxicity and
adverse events).
The primary objective of this study is to investigate if intensified chemotherapy followed by consolidating high-dose chemotherapy and autologous stem-cell transplantation (HDTASCT) is superior to conventional chemotherapy with R-MP followed by maintenance in
elderly patients with newly diagnosed PCNSL regarding 1-year progression free survival (PFS). Secondary objectives are the investigation of quality of life, remission after treatment, event free survival, overall survival (OS) and treatment related morbidities (neurotoxicity and
adverse events).
