With the publication of the long-term data from the RELAZA2 study, a research program developed over many years by Dresden University Medicine for the treatment of leukemia patients, has reached an important milestone. The results demonstrate the potential of early, minimal residual disease (MRD)-guided therapy to delay or possibly prevent relapses. RELAZA2 is considered the world’s first MRD-triggered prospective study in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML).
In recognition of her work on AI-supported cancer surgery, Clinician Scientist Dr. Fiona Kolbinger, MD, PhD, receives the 2026 Jung Career Advancement Award today in Hamburg, endowed with 210,000 euros. The Jung Foundation for Science and Research presents a total of three medical awards, endowed with more than 500,000 euros.
Researchers at Dresden University Hospital may have discovered a new therapeutic approach for treating myelodysplastic syndromes (MDS). In a recent study, the team headed by Prof. Manja Wobus and Dr. Katja Sockel demonstrated that the anti-inflammatory drug tasquinimod improves blood formation—which is impaired in MDS—and reduces bone damage in preclinical models. Their findings address two central and closely related clinical issues associated with MDS. The corresponding study on the preclinical efficacy of tasquinimod in myelodysplastic syndromes was recently published in the journal “HemaSphere,” a specialist journal for hematology.
Acute myeloid leukemia (AML) is a particularly aggressive form of blood cancer that usually progresses rapidly if swift and intensive treatment is not applied. Although the disease can often be contained by chemotherapy (remission), it returns in many patients. A permanent cure is often only possible with a stem cell transplant - provided that the leukemia can be sufficiently contained beforehand. A new Germany-wide study led by the Dresden University Medicine has shown that the combination of intensive chemotherapy and the substance venetoclax can significantly improve the success rate of treatment of aggressive acute leukemia. This has been confirmed by the results of RELAX, with remission in 75% of the cases compared to the past attempts yielding an only 40 percent remission rate. The study was published today, March 4, in the renowned journal The Lancet Haematology.
Better treatment for blood cancer: study starts in Dresden and KielAt the beginning of 2026, RELEVANT (ETAL-5), currently Germany’s largest study on allogeneic stem cell transplantation for patients suffering from Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS), was launched. For many of these diseases, stem cell transplantation is currently the only curative treatment option. The study, led by researchers from Dresden and Kiel, aims to improve treatment options and long-term survival for older patients or patients with preexisting comorbidities.
Nutrition is an essential part of cancer treatment, as it has a significant influence on the course of the disease, the tolerability of the therapy and the quality of life. Structured, nutritional therapy by qualified specialists helps to prevent malnutrition, can improve the patients’ response to therapies, reduce side effects, strengthen the immune system and improve their general well-being.
On the occasion of International Childhood Cancer Day (ICCD) on February 15, the Pediatric Oncology Center at the National Center for Tumor Diseases (NCT/UCC) Dresden is drawing attention to two new, pioneering care projects that have been launched in Saxony. The goal is to enable children and adolescents with cancer, as well as their families, to access to the best possible university-level care regardless of where they live.
World Cancer Day on February 4 provides an opportunity to focus on rare tumor diseases such as primary brain tumors. Owing to their location, these tumors pose particular challenges for patients, their families, and the healthcare system. Diagnosis is complex and treatment highly specialized, as as these tumors arise in close proximity to the brain, cranial nerves, sensory organs, and major central blood vessels. In Germany, there are only 20 to 25 new cases per 100,000 inhabitants each year; nevertheless, the functional impact of primary brain tumors can be severe.
A study by the Mildred Scheel Early Career Center group led by Dr. Mohamed Elgendy at the TUD Faculty of Medicine provides fundamental insights into cancer biology. Published in the renowned journal Nature Communications, the study shows for the first time that the protein MCL1 not only inhibits programmed cell death, but also plays a central role in tumor metabolism.
The National Center for Tumor Diseases (NCT/UCC) Dresden has been combining scientific innovation and modern patient care under one roof for the last ten years. Experts from the fields of medicine, research and technology cooperate closely to significantly improve the diagnosis and treatment of cancer. Thanks to strong ties with the University Cancer Center (UCC), founded in 2003, and the interplay of clinical expertise, high-tech infrastructure and interdisciplinary research, NCT/UCC represents a center in Dresden that has set high standards throughout Germany.
The PROSa+ study is the first study in Germany to focus on the quality of life and healthcare experiences of long-term survivors of sarcoma. Recruitment will begin in December 2025. Individuals whose sarcoma diagnosis dates back at least five years are invited to participate in the nationwide survey.
Under the leadership of Prof. Jakob N. Kather, Professor of Clinical Artificial Intelligence at EKFZ for Digital Health, TUD, and Dresden University Hospital Carl Gustav Carus (NCT/UCC), an international expert panel has developed guidelines for the safe use of large language models (LLMs) in oncology. Prof. Stephen Gilbert and Dr. med. Isabella Wiest, EKFZ for Digital Health, also contributed their expertise. The initiative was convened under the European Society for Medical Oncology (ESMO) as part of its “Real World Data & Digital Health Task Force”. The new framework aims to help patients, clinicians and institutions to adopt AI language tools responsibly.
A review analyzes over 13,000 publications covering this topic. From this, scientists extracted 32 recommendations for long-term, efficient, and tailored follow-up care for young patients.
Dr. Helena Jambor, a molecular biologist at the University of Applied Sciences of the Grisons in Chur and the Faculty of Medicine at TU Dresden with the NCT/UCC Dresden, has now developed a practice-oriented checklist to help researchers design clear and effective scientific figures. The accompanying paper and the checklist were recently published in the journal Nature Cell Biology.
The NCT is supporting a promising new treatment approach for patients with advanced solid tumors. A newly developed TCR-T cell therapy will undergo its first clinical testing in the multicenter ToMA4TA1 trial starting in 2027.
As part of a clinical trial, the National Center for Tumor Diseases (NCT/UCC) Dresden is now offering patients with pancreatic cancer (pancreatic carcinoma) the opportunity to participate in an innovative treatment using a personalized mRNA-based cancer vaccine following surgery.
So far, there is little scientific knowledge about the life situation of long-term sarcoma survivors. Researchers under the leadership of the National Center for Tumor Diseases (NCT/UCC) Dresden want to close this gap by conducting the “PROSa+” clinical trial and by systematically recording the needs and risks of this patient group.
An interdisciplinary research group at the National Center for Tumor Diseases (NCT/UCC) Dresden, a joint institution of the German Cancer Research Center (DKFZ), the Faculty of Medicine at TUD, University Hospital Dresden, and the Helmholtz-Zentrum Dresden-Rossendorf, has been able to make a human genetic diagnosis for a family using an innovative sequencing method. The study “Long-read genome and RNA sequencing resolve a pathogenic intronic germline LINE-1 insertion in APC” by Dresden University Medical Center has now been published in npj Genomic Medicine.
An international research group led by scientists from the National Center for Tumor Diseases (NCT/UCC) in Dresden has now succeeded for the first time in a phase 1 clinical trial in testing a novel cell therapy approach that also shows promise for solid tumors. The results were now published in the renowned journal Nature Medicine.