DESTINY-Lung04 (AstraZeneca)

{ "short_title": "DESTINY-Lung04 (AstraZeneca)", "data_mode": "900", "data_mode_number": "000002234", "official_title": "An Open-label, Randomized, Multicenter, Phase 3 Study to Assess the Efficacy and Safety of Trastuzumab Deruxtecan as First-line Treatment of Unresectable, Locally Advanced, or Metastatic NSCLC Harboring HER2 Exon 19 or 20 Mutations (DESTINY-Lung04)", "accrual_state": "running", "therapeutic_value": "therapeutic", "therapieansatz_value": "palliativ", "therapieintervention_value": "not_applicable", "therapielinie_value": "first", "ctgov_number": "NCT05048797", "eudract_number": "2021-000634-33", "general_contact_email": "oncostudy@ukdd.de", "general_contact_phone": "+49 351-4587666", "hauptpruefer_dd_name": "Prof. Dr. med. habil Martin Wermke", "description_laie_de": "DESTINY-Lung04 wird die Wirksamkeit und Sicherheit von Trastuzumab Deruxtecan (T-DXd) im Vergleich zur Standardtherapie (SoC) als Erstlinienbehandlung von nicht-kleinzelligem Lungenkrebs (NSCLC) mit HER2 Exon 19 oder 20 Mutationen untersuchen", "description_laie_en": "DESTINY-Lung04 will investigate the efficacy and safety of Trastuzumab Deruxtecan (T-DXd) versus Standard of Care (SoC) as first-line treatment of Non-Small Cell Lung Cancer (NSCLC) with HER2 Exon 19 or 20 mutations", "description_expert_de": "DESTINY-Lung04 wird die Wirksamkeit und Sicherheit von Trastuzumab Deruxtecan (T-DXd) im Vergleich zur Standardtherapie (SoC) als Erstlinienbehandlung von nicht-kleinzelligem Lungenkrebs (NSCLC) mit HER2 Exon 19 oder 20 Mutationen untersuchen", "description_expert_en": "DESTINY-Lung04 will investigate the efficacy and safety of Trastuzumab Deruxtecan (T-DXd) versus Standard of Care (SoC) as first-line treatment of Non-Small Cell Lung Cancer (NSCLC) with HER2 Exon 19 or 20 mutations", "rechtsgrundlage_value": "AMG", "phase_amg_value": "III", "main_cat_id": 10, "sub_cat_id": 50 }