NCT/UCC Core Unit: Outcome and health-services research

Patient-Reported Outcomes (PRO) are playing an important role in determining the health status of tumor patients. They are used to measure the health conditions of patients in many aspects (physical, mental, social) and they are utilized for a wide range of purposes from clinical trials to everyday care to health-services research.

Our core unit works on the electronic collection of patient-reported outcomes. PROs should be of immediate use for health care professionals and directly integrated in medical practice. In close cooperation with other departments and institutions we conduct studies that evaluate, develop and use patient-reported outcomes and promote their implementation in healthcare practice.

Figure: Health-Related Quality of life data (Questionnaire: EORTC QLQ C30) from 420 NCT/ UCC Cancer patients (2019). Thresholds for clinical importance accoring to Giesinger 2019 (https://doi.org/10.1016/j.jclinepi.2019.10.003).

Selected projects:

  • ePRO: Implementation of electronic recording of patient-reported outcomes in oncology care.
  • EORTC Questionnaire Development: Participation in the development of quality-of-life-related questionnaires under the auspices of the EORTC Quality-of-Life Group (https://qol.eortc.org/).
  • Corona and Cancer (WIBCE): Assessment of psychological distress, care situation as well as quality of life of cancer patients during the COVID19 pandemic.
  • Opti-Screen: Optimized psycho-oncology care through an interdisciplinary care algorithm - from screening to intervention.
  • PrePP (Prediction Readmission in Palliative Patients): Identifying risk factors for unplanned readmission in specialized outpatient palliative care
  • PROSa: Burden and medical care of sarcoma in Germany: Nationwide cohort study focusing on modifiable determinants of Patient-Reported Outcome measures in Sarcoma patients

Contact

Dr. Martin Eichler
Phone: +49 (0)351 458 19057
E-mail: martin.eichler(at)uniklinikum-dresden.de

Recent publications

2022

  • Martin Eichler, Susanne Singer, Leopold Hentschel, Beate Hornemann, Peter Hohenberger, Bernd Kasper, Dimosthenis Andreou, Daniel Pink, Sergio Armando Zapata Bonilla, Marius Fried, Karin Arndt, Martin Bornhäuser, Jochen Schmitt, Markus K. Schuler, Die psychoonkologische Versorgungssituation von Patienten mit Weichteilsarkomen – Resultate einer deutschen multizentrischen Beobachtungsstudie (PROSa), Die Onkologie, https://doi.org/10.1007/s00761-022-01245-1
  • Benjamin Thomas, Amir K. Bigdeli, Steffen Nolte, Emre Gazyakan, Leila Harhaus, Oliver Bischel, Burk-hard Lehner, Gerlinde Egerer, Gunhild Mechtersheimer, Peter Hohenberger, Raymund E. Horch, Dimosthenis Andreou, Jochen Schmitt, Markus K. Schuler, Martin Eichler, Ulrich Kneser: The Therapeutic Role of Plastic and Reconstructive Surgery in the Interdisciplinary Treatment of Soft Tissue and Bone Sar-comas in Germany — Cross-Sectional Results of a Prospective Nationwide Observational Study (PROSa), Cancers, https://doi.org/10.3390/cancers14174312
  • Martin Eichler, Leopold Hentschel, Susanne Singer, Beate Hornemann, Peter Hohenberger, Bernd Kasper, Dimosthenis Andreou, Daniel Pink, Jens Jakob, Karin Arndt, Johanna Kirchberg, Stephan Richter, Martin Bornhäuser, Jochen Schmitt, Markus K. Schuler: Distress in soft-tissue sarcoma and GIST patients —Results of a German multicentre observational study (PROSa), Psycho-Oncology, https://doi.org/10.1002/pon.6009
  • Waldemar Hahn, Katharina Schütte, Kristian Schultz, Olaf Wolkenhauer, Martin Sedlmayr, Ulrich Schuler, Martin Eichler, Saptarshi Bej, Markus Wolfien: Contribution of Synthetic Data Generation towards an Improved Patient Stratification in Palliative Care, Journal of Personalized Medicine, 2022; 12(8):1278, https://doi.org/10.3390/jpm12081278
  • Jens Jakob, Leopold Hentschel, Stephan Richter, Inga Kreisel, Peter Hohenberger‚ Bernd Kasper, Dimosthenis Andreou, Daniel Pink, Jochen Schmitt, Markus K. Schuler, Martin Eichler: Validating the health-related quality of life of retroperitoneal sarcoma patients as measured in the PROSA-study, Oncol Res Treat, 10.1159/000525288
  • Martin Eichler, Leopold Hentschel, Susanne Singer, Beate Hornemann, Stephan Richter, Peter Hohenberger, Bernd Kasper, Dimosthenis Andreou, Daniel Pink, Jens Jakob, Karin Arndt, Martin Bornhäuser, Jochen Schmitt, Markus K. Schuler, Psychische Verfassung und psychosoziale Versorgungssituation von Patienten mit Knochensarkomen – Resultate einer deutschen multizentrischen Beobachtungsstudie (PROSa), Der Onkologe, 10.1007/s00761-022-01098-8
  • Marieke van Leeuwen, Jacobien M. Kieffer, Martin Eichler, Teresa E. Young, Neil K. Aaronson, Lonneke V. van de Poll et. al: Phase III study of the European Organisation for Research and Treatment of Cancer: Quality of Life cancer survivorship core questionnaire, Journal of Cancer Survivorship, https://doi.org/10.1007/s11764-021-01160-1
  • Martin Eichler, Susanne Singer, Leopold Hentschel, Stephan Richter, Peter Hohenberger, Bernd Kasper, Dimosthenis Andreou, Daniel Pink, Jens Jakob, Robert Grützmann; Stephen Fung; Eva Wardelmann, Karin Arndt, Vitali Heidt, Sergio Armando Zapata Bonilla, Verena I. Gaidzik, Helena K. Jambor, Jürgen Weitz, Klaus-Dieter Schaser, Martin Bornhäuser, Jochen Schmitt, Markus K. Schuler: The association of Health-Related Quality of Life and 1-year-survival in sarcoma patients - Results of a Nationwide Observational Study (PROSa), BJC, https://doi.org/10.1038/s41416-022-01702-z

2021

  • Martin Eichler, Daniel Pink, Franka Menge, Jens Jakob, Leopold Hentschel, Stephan Richter, Peter Hohenberger, Bernd Kasper, Dimosthenis Andreou, Susanne Singer, Robert Grützmann, Diana I. Dmytrow, Karin Arndt, Armin Tuchscherer, Peter Reichardt, Marit Ahrens, Annegret Kunitz, Johannes Mohm, Martin Bornhäuser, Jochen Schmitt, Markus K. Schuler: Quality of life of GIST patients with and without current tyrosine kinase inhibitor treatment: Cross-sectional results of a German multicentre observational study (PROSa), European Journal of Cancer Care,  10.1111/ecc.13484
  • Ilse van Eck, Dide den Hollander, Emma Lidington, Leopold Hentschel, Martin Eichler, Samer Salah, Susanne Singer, Monica Pinto, Lena Fauske, Marco Fiore, Ioanna Nixon, Anastasia Constantinidou, Ingrid M.E. Desar, Johannes J. Bonenkamp, Winan J. van Houdt, Milou J.P. Reuvers, Rick L. M. Haas, Øyvind S. Bruland, Bernd Kasper, Winette T.A. van der Graaf, Olga Husson: Health-Related Quality of Life Issues Experienced by Thoracic and Breast Sarcoma Patients: A Rare and Understudied Group. Journal of Clinical Medicine, https://doi.org/10.3390/jcm10225334
  • Matthias Büttner, Susanne Singer, Leopold Hentschel, Stephan Richter, Peter Hohenberger, Bernd Kasper, Dimosthenis Andreou, Daniel Pink, Kathy Taylor, Karin Arndt, Martin Bornhäuser, Jochen Schmitt, Markus K. Schuler, Martin Eichler: Financial toxicity in sarcoma patients and survivors in Germany: results from the multicenter PROSa study, Support Care Cancer (2021). https://doi.org/10.1007/s00520-021-06406-3
  • Stephen Fung, Hany Ashmawy, Anja Schauer, Martin Eichler, Sami Safi, Levent Dizdar, Alexander Rehders, Wolfram Trudo Knoefel, Georg Fluegen: Does Video-Assisted Thoracoscopic Surgery with Bullectomy and Partial Pleurectomy for Primary Spontaneous Pneumothorax Impair Health-Related Quality of Life and Pulmonary Function?, Healthcare 2021, 9(11), 1463; https://doi.org/10.3390/healthcare9111463
  • Doris Janssen, Katharina Lingelbach, Sabrina Gado, Philipp Maurer, Daniela Piechnik, Martin Eichler, Dennis Knopf, Leopold Hentschel, Markus Schuler, Daniel Sernatinger Matthias Peissner: WIBCE – A Web Application Helping People to Reflect Their Infection Risk and Psychological Well-Being and Act Accordingly During the COVID-19 Pandemic, in: J. Kalra et al. (Eds.): AHFE 2021, LNNS 263, pp. 515–522, 2022, https://doi.org/10.1007/978-3-030-80744-3_64
  • Katharina Lingelbach, Daniela Piechnik, Sabrina Gado, Doris Janssen, Martin Eichler, Leopold Hentschel, Dennis Knopf, Markus Schuler, Daniel Sernatinger, Matthias Peissner: Effects of the COVID-19 Pandemic on Psychological Well-being and Mental Health, Front. Public Health 9:655083, DOI: 10.3389/fpubh.2021.655083
  • Katharina Lingelbach, Sabrina Gado, Doris Janssen, Daniela Piechnik, Martin Eichler, Dennis Knopf, Leopold Hentschel, Markus Schuler, Daniel Sernatinger, Matthias Peissner: Identifying the Effects of COVID-19 on Psychological Well-Being Through Unsupervised Clustering for Mixed Data. In: Yang XS., Sherratt S., Dey N., Joshi A. (eds) Proceedings of Sixth International Congress on Information and Communication Technology. Lecture Notes in Networks and Systems, vol 235. Springer, Singapore. https://doi.org/10.1007/978-981-16-2377-6_81
  • Martin Eichler, Dimosthenis Andreou, Henriette Golcher, Leopold Hentschel, Stephan Richter, Peter Hohenberger, Bernd Kasper, Daniel Pink, Jens Jakob, Hany Ashmawy, Simone Hettmer, Armin Tuchscherer, Matthias Grube, Vitali Heidt, Christina Jentsch, Jessica Pablik, Eva Wardelmann, Karl-Friedrich Kreitner, Ulrich Kneser, Carolin Tonus, Pauline Wimberger, Olaf Schoffer, Peter Reichardt, Markus Wartenberg, Maria Eberlein-Gonska, Martin Bornhäuser, Jochen Schmitt, Markus K. Schuler: Utilization of Interdisciplinary Tumor Boards for Sarcoma Care in Germany: Results from the PROSa Study, Oncol Res Treat,
  • https://doi.org/10.1159/000516262

2020

  • Martin Eichler, Leopold Hentschel, Stephan Richter, Peter Hohenberger, Bernd Kasper, Dimosthenis Andreou, Daniel Pink, Jens Jakob, Susanne Singer, Robert Grützmann, Stephen Fung, Eva Wardelmann, Karin Arndt, Vitali Heidt, Christine Hofbauer, Marius Fried, Verena I. Gaidzik, Karl Verpoort, Marit Ahrens, Jürgen Weitz, Klaus-Dieter Schaser, Martin Bornhäuser, Jochen Schmitt, Markus K. Schuler and the PROSa Study Group: The Health-Related Quality of Life of Sarcoma Patients and Survivors in Germany—Cross-Sectional Results of a Nationwide Observational Study (PROSa), Cancers 2020, 12, 3590; Doi:10.3390/cancers12123590
  • Schuler, M. K., Günther, M., Jaehde, U., & Hentschel, L. (2020). Lebensqualität in der digitalen Transformation. Forum, 1–5. https://doi.org/10.1007/s12312-020-00842-8
  • Hentschel L, Richter S, Kopp HG, et al (2020) Quality of life and added value of a tailored palliative care intervention in patients with soft tissue sarcoma undergoing treatment with trabectedin: a multicentre, cluster-randomised trial within the German Interdisciplinary Sarcoma Group (GISG). BMJ Open 10:e035546. https://doi.org/10.1136/bmjopen-2019-035546
  • Martin Eichler: Das menschliche Urteil in der evidenzbasierten Medizin, Der Onkologe, DOI: 10.1007/s00761-020-00720-x

2019

  • Martin Eichler, Marlene Hechtner, Beatrice Wehler, Roland Buhl, Martin Sebastian, Jan Stratmann, Heinz Schmidberger, Cornelius Kortsik, Ursula Nestle, Hubert Wirtz, Thomas Wehler, Maria Blettner, Susanne Singer: Use of psychosocial services by lung cancer survivors in Germany.  Results of a German multicenter study (LARIS), Strahlentherapie und Onkologie, https://doi.org/10.1007/s00066-019-01490-1
  • Martin Eichler, Jochen Schmitt, Markus K Schuler: Die Dauer von Ethikvoten in Deutschland – am Beispiel einer nicht –interventionellen Beobachtungsstudie mit 44 teilnehmenden Zentren (PROSa), ZEFQ - Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen, https://doi.org/10.1016/j.zefq.2019.07.006
  • Markus Schuler, Leopold Hentschel: Lebensqualität beim kolorektalen Karzinom – Was wir noch lernen können, Journal Onkologie 4/2019

2018

  • Marieke van Leeuwen, Olga Husson, Paola Alberti, Juan Ignacio Arraras,  Olivier L. Chinot, Anna Costantini, Anne-Sophie Darlington, Linda Dirven, Martin Eichler, Eva B. Hammerlid, Bernhard Holzner, Colin D. Johnson, Meropi Kontogianni, Trille Kristina Kjær, Ofir Morag, Sandra Nolte, Andrew Nordin, Andrea Pace, Monica Pinto, Katja Polz, John Ramage, Jaap C. Reijneveld, Samantha Serpentini, Krzysztof A. Tomaszewski, Vassilios Vassiliou, Irma M. Verdonck-de Leeuw, Ingvild Vistad, Teresa E. Young, Neil K. Aaronson, Lonneke V. van de Poll-Franse: Understanding the quality of life (QOL) issues in survivors of cancer: towards the development of an EORTC QOL cancer survivorship questionnaire, Health and Quality of Life Outcomes (2018) 16:114, https://doi.org/10.1186/s12955-018-0920-0

2017

  • Markus Schuler, F. Trautmann, M. Radloff, L. Hentschel, T. Petzold, M. Eberlein-Gonska, G. Ehninger, J. Schmitt (2017) Implementation and first results of a tablet-based assessment referring to Patient-Reported Outcomes in an inpatient cancer care unit. Z. Evid. Fortbild. Qual. Gesundh.wesen (ZEFQ).
  • M. Schuler, J. Schildmann, F. Trautmann, L. Hentschel, B. Hornemann, A. Rentsch, G. Ehninger, J. Schmitt (2017) Cancer patients' control preferences in decision making and associations with patient-reported outcomes: a prospective study in an outpatient cancer center. Support Care Cancer.

2016

  • F. Trautmann, L. Hentschel, B. Hornemann, A. Rentsch, M. Baumann, G. Ehninger, J. Schmitt, M. Schuler (2016) Electronic real-time assessment of patient-reported outcomes in routine care – first findings and experiences from the implementation in a comprehensive cancer center. Supportive Care in Cancer, 24(7):3047-3056.
  • M. Schuler, F. Trautmann, M. Radloff, R. Schmädig, L. Hentschel, M. Eberlein-Gonska, T. Petzold, H. Vetter, S. Oberlack, G. Ehninger, J. Schmitt (2016) Implementation of a mobile inpatient quality of life (QoL) assessment for oncology nursing. Supportive Care in Cancer, 24(8):3391-9.