NCT/UCC Core Unit: Outcome and health-services research

Patient-Reported Outcomes (PRO) are playing an important role in determining the health status of tumor patients. They are used to measure the health conditions of patients in many aspects (physical, mental, social) and they are utilized for a wide range of purposes from clinical trials to everyday care to health-services research.

Our core unit works on the electronic collection of patient-reported outcomes. PROs should be of immediate use for health care professionals and directly integrated in medical practice. In close cooperation with other departments and institutions we conduct studies that evaluate, develop and use patient-reported outcomes and promote their implementation in healthcare practice.

Figure: Health-Related Quality of life data (Questionnaire: EORTC QLQ C30) from 420 NCT/ UCC Cancer patients (2019). Thresholds for clinical importance accoring to Giesinger 2019 (

Selected projects:

  • ePRO: Implementation of electronic recording of patient-reported outcomes in oncology care.
  • EORTC Questionnaire Development: Participation in the development of quality-of-life-related questionnaires under the auspices of the EORTC Quality-of-Life Group (
  • Corona and Cancer (WIBCE): Assessment of psychological distress, care situation as well as quality of life of cancer patients during the COVID19 pandemic.
  • Opti-Screen: Optimized psycho-oncology care through an interdisciplinary care algorithm - from screening to intervention.
  • PrePP (Prediction Readmission in Palliative Patients): Identifying risk factors for unplanned readmission in specialized outpatient palliative care
  • PROSa: Burden and medical care of sarcoma in Germany: Nationwide cohort study focusing on modifiable determinants of Patient-Reported Outcome measures in Sarcoma patients


Dr. Martin Eichler
Phone: +49 (0)351 458 19057
E-mail: martin.eichler(at)


  • Martin Eichler, Leopold Hentschel, Stephan Richter, Peter Hohenberger, Bernd Kasper, Dimosthenis Andreou, Daniel Pink, Jens Jakob, Susanne Singer, Robert Grützmann, Stephen Fung, Eva Wardelmann, Karin Arndt, Vitali Heidt, Christine Hofbauer, Marius Fried, Verena I. Gaidzik, Karl Verpoort, Marit Ahrens, Jürgen Weitz, Klaus-Dieter Schaser, Martin Bornhäuser, Jochen Schmitt, Markus K. Schuler and the PROSa Study Group: The Health-Related Quality of Life of Sarcoma Patients and Survivors in Germany—Cross-Sectional Results of a Nationwide Observational Study (PROSa), Cancers 2020, 12, 3590; Doi:10.3390/cancers12123590
  • Schuler, M. K., Günther, M., Jaehde, U., & Hentschel, L. (2020). Lebensqualität in der digitalen Transformation. Forum, 1–5.
  • Hentschel L, Richter S, Kopp HG, et al (2020) Quality of life and added value of a tailored palliative care intervention in patients with soft tissue sarcoma undergoing treatment with trabectedin: a multicentre, cluster-randomised trial within the German Interdisciplinary Sarcoma Group (GISG). BMJ Open 10:e035546.
  • Martin Eichler: Das menschliche Urteil in der evidenzbasierten Medizin, Der Onkologe, DOI: 10.1007/s00761-020-00720-x


  • Martin Eichler, Marlene Hechtner, Beatrice Wehler, Roland Buhl, Martin Sebastian, Jan Stratmann, Heinz Schmidberger, Cornelius Kortsik, Ursula Nestle, Hubert Wirtz, Thomas Wehler, Maria Blettner, Susanne Singer: Use of psychosocial services by lung cancer survivors in Germany.  Results of a German multicenter study (LARIS), Strahlentherapie und Onkologie,
  • Martin Eichler, Jochen Schmitt, Markus K Schuler: Die Dauer von Ethikvoten in Deutschland – am Beispiel einer nicht –interventionellen Beobachtungsstudie mit 44 teilnehmenden Zentren (PROSa), ZEFQ - Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen,
  • Markus Schuler, Leopold Hentschel: Lebensqualität beim kolorektalen Karzinom – Was wir noch lernen können, Journal Onkologie 4/2019


  • Marieke van Leeuwen, Olga Husson, Paola Alberti, Juan Ignacio Arraras,  Olivier L. Chinot, Anna Costantini, Anne-Sophie Darlington, Linda Dirven, Martin Eichler, Eva B. Hammerlid, Bernhard Holzner, Colin D. Johnson, Meropi Kontogianni, Trille Kristina Kjær, Ofir Morag, Sandra Nolte, Andrew Nordin, Andrea Pace, Monica Pinto, Katja Polz, John Ramage, Jaap C. Reijneveld, Samantha Serpentini, Krzysztof A. Tomaszewski, Vassilios Vassiliou, Irma M. Verdonck-de Leeuw, Ingvild Vistad, Teresa E. Young, Neil K. Aaronson, Lonneke V. van de Poll-Franse: Understanding the quality of life (QOL) issues in survivors of cancer: towards the development of an EORTC QOL cancer survivorship questionnaire, Health and Quality of Life Outcomes (2018) 16:114,


  • Markus Schuler, F. Trautmann, M. Radloff, L. Hentschel, T. Petzold, M. Eberlein-Gonska, G. Ehninger, J. Schmitt (2017) Implementation and first results of a tablet-based assessment referring to Patient-Reported Outcomes in an inpatient cancer care unit. Z. Evid. Fortbild. Qual. Gesundh.wesen (ZEFQ).
  • M. Schuler, J. Schildmann, F. Trautmann, L. Hentschel, B. Hornemann, A. Rentsch, G. Ehninger, J. Schmitt (2017) Cancer patients' control preferences in decision making and associations with patient-reported outcomes: a prospective study in an outpatient cancer center. Support Care Cancer.


  • F. Trautmann, L. Hentschel, B. Hornemann, A. Rentsch, M. Baumann, G. Ehninger, J. Schmitt, M. Schuler (2016) Electronic real-time assessment of patient-reported outcomes in routine care – first findings and experiences from the implementation in a comprehensive cancer center. Supportive Care in Cancer, 24(7):3047-3056.
  • M. Schuler, F. Trautmann, M. Radloff, R. Schmädig, L. Hentschel, M. Eberlein-Gonska, T. Petzold, H. Vetter, S. Oberlack, G. Ehninger, J. Schmitt (2016) Implementation of a mobile inpatient quality of life (QoL) assessment for oncology nursing. Supportive Care in Cancer, 24(8):3391-9.